Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 7/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664455 | 0.93 | HPGDS (0.46) | HPGDSTNIKMAPTRAB9AMAPK14 | |
| SCHEMBL13964567 | 0.81 | KMT2A (0.42) | TNIKRAB9AMAPK14DHODHEPHX2 | |
| SCHEMBL1664403 | 0.80 | BRD4 (0.57) | HPGDSRAB9AMAPK14BRD4JAK2 | |
| SCHEMBL1666783 | 0.79 | SMYD3 (0.46) | HPGDSTNIKMAPTRAB9ADHODH | |
| SCHEMBL28807458 | 0.79 | HPGDS (0.45) | HPGDSMAPTRAB9AMAPK14DHODH | |
| SCHEMBL1664447 | 0.78 | SMYD3 (0.43) | HPGDSMAPTRAB9ADHODHBRD4 | |
| SCHEMBL1666853 | 0.78 | BRD4 (0.45) | HPGDSMAPTRAB9ADHODHBRD4 | |
| SCHEMBL1666855 | 0.78 | BRD4 (0.47) | HPGDSMAPTRAB9AMAPK14DHODH | |
| SCHEMBL1664422 | 0.75 | HPGDS (0.47) | HPGDSMAPTRAB9AMAPK14DHODH | |
| SCHEMBL1664463 | 0.75 | KCNK3 (0.49) | MAPTRAB9ADHODHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |