Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | ODC1 | P11926 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13073183 | 0.91 | PAOX (0.40) | CYP1A2GSRCPB2ALDH1A1PAOX | |
| SCHEMBL27395534 | 0.86 | — | — | |
| SCHEMBL28268034 | 0.86 | NAAA (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4GRIN2D | |
| SCHEMBL28439905 | 0.86 | NAAA (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4GRIN2D | |
| SCHEMBL3138582 | 0.86 | — | — | |
| SCHEMBL15623821 | 0.86 | NAAA (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4GRIN2D | |
| SCHEMBL15802651 | 0.86 | NAAA (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4GRIN2D | |
| SCHEMBL15655433 | 0.86 | GAA (0.40) | CYP1A2THRBTSHRKMT2A | |
| SCHEMBL14391440 | 0.84 | CYP1A2 (0.40) | CYP1A2ODC1CPB2GABRR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28168281 | 0.84 | NAAA (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015195925-A1 | PROTEIN-POLYMER-DRUG CONJUGATES AND METHODS OF USING SAME | MERSANA THERAPEUTICS, INC. (US) | 2015-12-23 | — | — | WO | disclosed |
| WO-2015054659-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. (US) | 2015-04-16 | — | — | WO | disclosed |