Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 11/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664504 | 0.94 | HDAC8 (0.61) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL1663944 | 0.82 | MAPT (0.46) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL1663802 | 0.81 | HDAC8 (0.58) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL1663942 | 0.81 | RAB9A (0.44) | MAPTRAB9ANPC1TP53PKM | |
| SCHEMBL1664941 | 0.80 | NPC1 (0.67) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL8770431 | 0.80 | HDAC8 (0.81) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL1663783 | 0.80 | HDAC8 (0.81) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL1664814 | 0.78 | HDAC8 (0.60) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL6126073 | 0.78 | MAPT (0.60) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL1663807 | 0.76 | HDAC8 (0.64) | HDAC8HDAC6MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |