Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 3/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.50 |
| ▸ | STAT6 | P42226 | 2/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664511 | 0.93 | SMO (0.54) | SMOMAPK10MAPK8MAPK11MAPK14 | |
| SCHEMBL1665684 | 0.87 | MAPK10 (0.48) | SMOMAPK10MAPK8MAPK11MAPK14 | |
| SCHEMBL1663342 | 0.87 | MAOB (0.52) | SMOMAPK10MAPK8MAPK11MAPK14 | |
| SCHEMBL1666175 | 0.85 | JAK2 (0.53) | MAPK10MAPK8MAPK11MAPK14MAPK13 | |
| SCHEMBL1663344 | 0.83 | MAOB (0.56) | SMOMAPK10MAPK8MAPK11MAPK14 | |
| SCHEMBL11963718 | 0.83 | NR3C1 (0.49) | MAPK10MAPK8MAPK11MAPK14MAPK13 | |
| SCHEMBL1664474 | 0.81 | TNIK (0.46) | MAPK10MAPK8MAPK11MAPK14MAPK13 | |
| SCHEMBL1666461 | 0.81 | MAPT (0.50) | MAPK10MAPK8MAPK11MAPK14MAPK13 | |
| SCHEMBL1665685 | 0.80 | MAPK14 (0.45) | SMOMAPK10MAPK8MAPK11MAPK14 | |
| SCHEMBL1663875 | 0.80 | TDP1 (0.47) | MAPK10MAPK8MAPK11MAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |