Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 11/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563728 | 0.81 | ALDH1A1 (0.54) | ABCG2ABCB1KDM4EALDH1A1GAA | |
| SCHEMBL3958744 | 0.81 | ABCG2 (0.52) | ABCG2ABCB1KDM4EALDH1A1GAA | |
| SCHEMBL16481161 | 0.79 | KDM4E (0.49) | ABCG2ABCB1KDM4EALDH1A1GAA | |
| SCHEMBL5896060 | 0.78 | MERTK (0.50) | ABCG2ABCB1KDM4EALDH1A1GAA | |
| SCHEMBL20829078 | 0.78 | KDM4E (0.47) | ABCG2ABCB1KDM4EALDH1A1GAA | |
| SCHEMBL5901016 | 0.78 | GAA (0.65) | ABCG2ABCB1KDM4EALDH1A1GAA | |
| SCHEMBL16481462 | 0.78 | KDM4E (0.47) | ABCG2ABCB1KDM4EALDH1A1GAA | |
| SCHEMBL1617748 | 0.78 | MAPT (0.56) | KDM4EALDH1A1GAAEGFRTSHR | |
| SCHEMBL6034438 | 0.77 | ALDH1A1 (0.63) | KDM4EALDH1A1GAAACP1MAPT | |
| SCHEMBL510240 | 0.76 | ALDH1A1 (0.62) | ABCG2ABCB1KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |