Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | GAA | P10253 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28267713 | 0.82 | LOXL2 (0.83) | LOXL2MAPTKDM4ENPC1SIRT2 | |
| SCHEMBL27480926 | 0.81 | MAPK13 (0.65) | MAPTGAAKDM4ENPC1GFER | |
| SCHEMBL12374632 | 0.79 | MAPT (0.74) | MAPTGAAKDM4ENPC1GFER | |
| SCHEMBL9683164 | 0.79 | GAA (0.70) | MAPTGAAKDM4ENPC1GFER | |
| SCHEMBL144278 | 0.78 | MAPT (0.58) | MAPTGAAKDM4ENPC1GFER | |
| SCHEMBL20631545 | 0.78 | GAA (0.59) | MAPTGAAKDM4ENPC1GFER | |
| SCHEMBL30033633 | 0.78 | GAA (0.59) | MAPTGAAKDM4ENPC1GFER | |
| SCHEMBL3665143 | 0.77 | KDM4E (0.59) | MAPTGAAKDM4ENPC1GFER | |
| SCHEMBL4002584 | 0.77 | GAA (0.72) | MAPTGAAKDM4ENPC1GFER | |
| SCHEMBL184868 | 0.77 | LOXL2 (1.00) | LOXL2MAPTGAAKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |