Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A | Q12879 | 14/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 13/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 9/20 | 0.53 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16645746 | 0.89 | GRIN2A (0.51) | GRIN2AGRIN1GRIA2GRIN2DGRIN2C | |
| SCHEMBL17958280 | 0.89 | GRIN1 (0.58) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16637721 | 0.86 | GRIN1 (0.70) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645689 | 0.81 | GRIN2A (0.44) | GRIN2AGRIN1GRIA2GRIN2DGRIN2C | |
| SCHEMBL16636460 | 0.80 | GRIN1 (0.77) | GRIN2AGRIN1GRIA2CD38 | |
| SCHEMBL16645506 | 0.79 | GRIN1 (0.70) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645664 | 0.77 | GRIN2A (0.65) | GRIN2AGRIN1GRIA2GRIN2DGRIN2C | |
| SCHEMBL17958250 | 0.77 | GRIN1 (0.66) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645748 | 0.77 | GRIN1 (0.84) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645947 | 0.77 | GRIN1 (0.51) | GRIN2AGRIN1GRIA2CD38NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |