Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A | Q12879 | 14/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 12/20 | 0.54 |
| ▸ | GRIA2 | P42262 | 9/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17958172 | 0.90 | GRIN2A (0.66) | GRIN2AGRIN1GRIA2POLBAPEX1 | |
| SCHEMBL16645948 | 0.82 | GRIN2A (0.68) | GRIN2AGRIN1GRIA2GRIN2DGRIN2C | |
| SCHEMBL16645973 | 0.82 | GRIN2A (0.56) | GRIN2AGRIN1GRIA2MAPT | |
| SCHEMBL16636732 | 0.81 | GRIN2A (0.77) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645704 | 0.80 | GRIN2A (0.49) | GRIN2AGRIN1GRIA2POLBAPEX1 | |
| SCHEMBL16645714 | 0.79 | MAPT (0.50) | GRIN2AGRIN1GRIA2MAPT | |
| SCHEMBL16645623 | 0.79 | GRIN2A (0.70) | GRIN2AGRIN1GRIA2POLBAPEX1 | |
| SCHEMBL16645808 | 0.77 | GRIN2A (0.66) | GRIN2AGRIN1GRIA2GRIN2DGRIN2C | |
| SCHEMBL16645693 | 0.76 | GRIN1 (0.66) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645692 | 0.75 | GRIN1 (0.56) | GRIN2AGRIN1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |