Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A | Q12879 | 13/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 11/20 | 0.56 |
| ▸ | GRIA2 | P42262 | 9/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17971492 | 0.91 | GRIN2A (0.67) | GRIN2AGRIN1GRIA2RXFP1TP53 | |
| SCHEMBL16645632 | 0.87 | GRIN2A (0.67) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645702 | 0.82 | GRIN2A (0.54) | GRIN2AGRIN1GRIA2MAPT | |
| SCHEMBL16645714 | 0.80 | MAPT (0.50) | GRIN2AGRIN1GRIA2RXFP1TP53 | |
| SCHEMBL16645948 | 0.78 | GRIN2A (0.68) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645704 | 0.77 | GRIN2A (0.49) | GRIN2AGRIN1GRIA2RXFP1TP53 | |
| SCHEMBL16645693 | 0.73 | GRIN1 (0.66) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL17958172 | 0.73 | GRIN2A (0.66) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL17971474 | 0.73 | GRIN2A (0.64) | GRIN2AGRIN1GRIA2RXFP1TP53 | |
| SCHEMBL16645692 | 0.73 | GRIN1 (0.56) | GRIN2AGRIN1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |