Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 19/20 | 0.61 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13059574 | 0.88 | S1PR1 (0.72) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1662792 | 0.85 | APP (0.50) | S1PR1APP | |
| SCHEMBL1661562 | 0.84 | S1PR1 (0.72) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1661676 | 0.84 | S1PR1 (0.65) | S1PR1S1PR3S1PR5 | |
| SCHEMBL3419145 | 0.83 | S1PR1 (0.73) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1662091 | 0.82 | S1PR1 (0.62) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1660273 | 0.82 | S1PR1 (0.62) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1664199 | 0.81 | S1PR1 (0.61) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1661761 | 0.78 | S1PR1 (0.60) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1661194 | 0.78 | S1PR1 (0.56) | S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |