Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 11/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664584 | 0.85 | S1PR1 (0.61) | APPS1PR1 | |
| SCHEMBL1661564 | 0.84 | S1PR1 (0.50) | APPMAOBS1PR1 | |
| SCHEMBL1661678 | 0.84 | S1PR1 (0.44) | APPMAOBS1PR1 | |
| SCHEMBL1662093 | 0.82 | S1PR1 (0.43) | MAOBS1PR1 | |
| SCHEMBL1660276 | 0.82 | ADORA3 (0.44) | MAOBS1PR1 | |
| SCHEMBL1664202 | 0.81 | S1PR1 (0.42) | APPMAOBS1PR1 | |
| SCHEMBL1661765 | 0.78 | S1PR1 (0.41) | MAOBS1PR1 | |
| SCHEMBL1661196 | 0.77 | S1PR1 (0.39) | GLAGAAMAOBS1PR1MAPT | |
| SCHEMBL1662682 | 0.76 | S1PR1 (0.38) | MAOBS1PR1 | |
| SCHEMBL1661460 | 0.76 | S1PR1 (0.38) | MAOBS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |