Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664705 | 0.92 | MAPT (0.50) | MAPTRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL1664957 | 0.90 | MGLL (0.43) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL1664618 | 0.83 | MAPT (0.46) | MAPTRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL1665787 | 0.83 | CRACR2A (0.50) | MAPTRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL1664960 | 0.82 | MGLL (0.46) | MAPTRAB9ASMN1; SMN2NPC1MAPK10 | |
| SCHEMBL13964699 | 0.81 | MAPT (0.49) | MAPTRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL1664485 | 0.80 | MAPT (0.46) | MAPTRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL1664258 | 0.79 | JAK2 (0.48) | MAPTSMN1; SMN2MAPK10MAPK8MAPK13 | |
| SCHEMBL1664913 | 0.79 | MAPT (0.59) | MAPTRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL1665048 | 0.78 | MAPT (0.46) | MAPTRAB9ASMN1; SMN2NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |