Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.47 |
| ▸ | PNMT | P11086 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16649843 | 1.00 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3PNMTAHR | |
| SCHEMBL1565324 | 1.00 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3PNMTAHR | |
| SCHEMBL2273892 | 0.83 | S1PR1 (0.43) | SLC6A4SLC6A2SLC6A3PNMTLMNA | |
| SCHEMBL5862322 | 0.82 | ADRB2 (0.56) | SLC6A4SLC6A2SLC6A3PNMTAHR | |
| SCHEMBL3181409 | 0.82 | ADRB2 (0.56) | SLC6A4SLC6A2SLC6A3PNMTAHR | |
| SCHEMBL61975 | 0.82 | ADRB2 (0.56) | SLC6A4SLC6A2SLC6A3PNMTAHR | |
| SCHEMBL29453111 | 0.82 | ADRB2 (0.56) | SLC6A4SLC6A2SLC6A3PNMTAHR | |
| SCHEMBL1556537 | 0.82 | APP (0.39) | SLC6A4SLC6A2SLC6A3PNMTADRB2 | |
| SCHEMBL16649917 | 0.80 | SLC6A2 (0.45) | SLC6A4SLC6A2SLC6A3PNMTAHR | |
| SCHEMBL16649763 | 0.80 | SLC6A2 (0.45) | SLC6A4SLC6A2SLC6A3PNMTAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |