Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 16/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5449353 | 1.00 | SLC6A4 (0.41) | SLC6A4SLC6A2SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL5463468 | 1.00 | SLC6A4 (0.41) | SLC6A4SLC6A2SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL16649546 | 0.87 | SLC6A2 (0.53) | SLC6A4SLC6A2SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL27940516 | 0.84 | SLC6A2 (0.50) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL12498003 | 0.84 | SLC6A2 (0.50) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5455487 | 0.81 | OPRM1 (0.38) | SLC6A4SLC6A2SLC6A3SCN4A | |
| SCHEMBL5456889 | 0.81 | OPRM1 (0.38) | SLC6A4SLC6A2SLC6A3SCN4A | |
| SCHEMBL20811251 | 0.81 | SLC6A4 (0.43) | SLC6A4SLC6A2SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL16649787 | 0.81 | SLC6A4 (0.43) | SLC6A4SLC6A2SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL17176032 | 0.80 | SLC6A4 (0.41) | SLC6A4SLC6A2SLC6A3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |