Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 13/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655530 | 0.88 | PI4KB (0.85) | PI4KBKCNH2CYP3A4KIT | |
| SCHEMBL655972 | 0.84 | PI4KB (0.69) | PI4KBKCNH2CYP3A4 | |
| SCHEMBL655275 | 0.84 | PI4KB (1.00) | PI4KBKCNH2CYP3A4KIT | |
| SCHEMBL654341 | 0.84 | PI4KB (0.73) | PI4KBKCNH2CYP3A4LMNACYP1A2 | |
| SCHEMBL656344 | 0.84 | PI4KB (0.84) | PI4KBKCNH2CYP3A4LMNACYP1A2 | |
| SCHEMBL653984 | 0.84 | PI4KB (0.73) | PI4KBKCNH2CYP3A4LMNACYP1A2 | |
| SCHEMBL653630 | 0.83 | PI4KB (0.60) | PI4KBKCNH2CYP3A4CYP1A2GBA1 | |
| SCHEMBL656322 | 0.82 | PI4KB (0.86) | PI4KBKCNH2CYP3A4LMNAKIT | |
| SCHEMBL794433 | 0.82 | PI4KB (0.57) | PI4KBKCNH2CYP3A4HRH4 | |
| SCHEMBL654265 | 0.82 | PI4KB (0.83) | PI4KBKCNH2CYP3A4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616077-B1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | UNIV LEUVEN KATH (BE) | 2016-08-31 | — | — | EP | claimed |
| EP-2405973-B1 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | UNIV LEUVEN KATH (BE) | 2015-04-22 | — | — | EP | claimed |