Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 16/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655068 | 0.86 | PI4KB (0.50) | PI4KBKCNH2CYP3A4 | |
| SCHEMBL653326 | 0.85 | PI4KB (0.56) | PI4KBKCNH2CYP3A4 | |
| SCHEMBL655537 | 0.84 | PI4KB (0.68) | PI4KBKCNH2CYP3A4 | |
| SCHEMBL652412 | 0.84 | PI4KB (0.65) | PI4KBKCNH2CYP3A4 | |
| SCHEMBL654023 | 0.83 | PI4KB (0.74) | PI4KBKCNH2CYP3A4 | |
| SCHEMBL652025 | 0.83 | PI4KB (0.67) | PI4KBKCNH2CYP3A4 | |
| SCHEMBL656641 | 0.83 | PI4KB (0.58) | PI4KBKCNH2CYP3A4 | |
| SCHEMBL16650147 | 0.82 | PI4KB (0.71) | PI4KBKCNH2CYP3A4HRH4 | |
| SCHEMBL651890 | 0.82 | HRH4 (0.54) | PI4KBKCNH2CYP3A4IKBKBHRH4 | |
| SCHEMBL656484 | 0.82 | NOS1 (0.44) | PI4KBKCNH2CYP3A4IKBKBHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616077-B1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | UNIV LEUVEN KATH (BE) | 2016-08-31 | — | — | EP | claimed |
| EP-2405973-B1 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | UNIV LEUVEN KATH (BE) | 2015-04-22 | — | — | EP | claimed |
| EP-2616077-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035423-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-03-22 | — | — | WO | disclosed |