Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665045 | 0.95 | KMT2A (0.42) | NPC1RAB9APKMLRRK2SMN1; SMN2 | |
| SCHEMBL1664923 | 0.88 | NPC1 (0.46) | NPC1RAB9APKMSMN1; SMN2CYP1A2 | |
| SCHEMBL1665170 | 0.85 | NPC1 (0.45) | NPC1RAB9APKMSMN1; SMN2CYP1A2 | |
| SCHEMBL6126242 | 0.85 | NPC1 (0.45) | NPC1RAB9APKMSMN1; SMN2CYP1A2 | |
| SCHEMBL6126046 | 0.83 | GPR6 (0.45) | NPC1RAB9APKMLRRK2SMN1; SMN2 | |
| SCHEMBL1665171 | 0.83 | SLC2A1 (0.45) | NPC1RAB9APKMSMN1; SMN2CYP1A2 | |
| SCHEMBL1664925 | 0.83 | SLC2A1 (0.45) | NPC1RAB9APKMSMN1; SMN2CYP1A2 | |
| SCHEMBL1664969 | 0.82 | KMT2A (0.41) | NPC1RAB9ALRRK2SMN1; SMN2HSD17B10 | |
| SCHEMBL6126243 | 0.81 | SLC2A1 (0.46) | NPC1RAB9APKMSMN1; SMN2CYP1A2 | |
| SCHEMBL1664971 | 0.80 | KMT2A (0.44) | NPC1RAB9ASMN1; SMN2HSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |