Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664923 | 0.97 | NPC1 (0.46) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6126242 | 0.96 | NPC1 (0.45) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1664925 | 0.94 | SLC2A1 (0.45) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1665171 | 0.94 | SLC2A1 (0.45) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6126243 | 0.90 | SLC2A1 (0.46) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1664481 | 0.87 | SMN1; SMN2 (0.45) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1664625 | 0.86 | RAB9A (0.48) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1664007 | 0.86 | RAB9A (0.51) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1665043 | 0.85 | NPC1 (0.42) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1663915 | 0.85 | PDE7A (0.42) | NPC1RAB9ASMN1; SMN2PDE7AHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |