Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 11/20 | 0.44 |
| ▸ | RAB9A | P51151 | 11/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665074 | 0.96 | RAB9A (0.52) | HPGDSNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1663915 | 0.90 | PDE7A (0.42) | HPGDSNPC1RAB9ANAMPTPDE7A | |
| SCHEMBL1664832 | 0.89 | PDE7A (0.41) | HPGDSNPC1RAB9ANAMPTPDE7A | |
| SCHEMBL1663917 | 0.86 | NPC1 (0.44) | HPGDSNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1664835 | 0.86 | NPC1 (0.44) | HPGDSNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1665239 | 0.85 | SMN1; SMN2 (0.46) | HPGDSNPC1RAB9APDE7ASMN1; SMN2 | |
| SCHEMBL1665243 | 0.82 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL1663400 | 0.82 | MAPT (0.46) | HPGDSNPC1RAB9APDE7ASMN1; SMN2 | |
| SCHEMBL8769706 | 0.80 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL1667499 | 0.79 | RAB9A (0.49) | HPGDSNPC1RAB9APDE7ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |