Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.36 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562127 | 0.74 | JAK1 (0.55) | JAK1JAK2JAK3AXLTYK2 | |
| SCHEMBL1662982 | 0.74 | JAK3 (0.42) | JAK1JAK2BTKJAK3TYK2 | |
| SCHEMBL1662557 | 0.73 | JAK3 (0.41) | JAK1JAK2BTKJAK3TYK2 | |
| SCHEMBL4562740 | 0.72 | JAK1 (0.55) | JAK1JAK2JAK3AXLTYK2 | |
| SCHEMBL4561997 | 0.72 | AXL (0.55) | JAK1JAK2JAK3AXLTYK2 | |
| SCHEMBL4561131 | 0.69 | JAK1 (0.53) | JAK1JAK2JAK3AXLTYK2 | |
| SCHEMBL16513437 | 0.69 | IGF1R (0.42) | JAK1JAK3AXLIGF1RCCNB2 | |
| SCHEMBL4534744 | 0.68 | JAK1 (0.51) | JAK1JAK2JAK3AXLTYK2 | |
| SCHEMBL4561182 | 0.68 | JAK1 (0.52) | JAK1JAK2JAK3AXLTYK2 | |
| SCHEMBL1662711 | 0.68 | JAK3 (0.42) | JAK1JAK2BTKJAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |