Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.56 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 6/20 | 0.41 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.41 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | LAP3 | P28838 | 4/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL2286761 | 0.98 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2CA2ANPEP | |
| Leucine SCHEMBL9581376 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2CA2ANPEP | |
| Leucine SCHEMBL3285972 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2CA2ANPEP | |
| Leucine SCHEMBL30109857 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2CA2ANPEP | |
| Leucine SCHEMBL3362640 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2CA2ANPEP | |
| Leucine SCHEMBL7781917 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2CA2ANPEP | |
| Leucine SCHEMBL10619258 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2CA2ANPEP | |
| Leucine SCHEMBL8802761 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2CA2ANPEP | |
| Leucine SCHEMBL9303138 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2CA2ANPEP | |
| Leucine SCHEMBL9453845 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2CA2ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10105500-B2 | Dry powder inhaler (DPI) designs for producing aerosols with high fine particle fractions | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2018-10-23 | — | — | US | disclosed |
| US-20150107589-A1 | DRY POWDER INHALER (DPI) DESIGNS FOR PRODUCING AEROSOLS WITH HIGH FINE PARTICLE FRACTIONS | VIRGINIA COMMONWEALTH UNIVERSITY | 2015-04-23 | — | — | US | disclosed |