Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665214 | 0.93 | NPC1 (0.53) | NPC1RAB9AGFERTNIKMAPK10 | |
| SCHEMBL1665597 | 0.86 | NPC1 (0.44) | NPC1RAB9ATNIKMAPK10MAPK8 | |
| SCHEMBL1665067 | 0.86 | MAPK10 (0.42) | NPC1RAB9ATNIKMAPK10MAPK8 | |
| SCHEMBL1664303 | 0.86 | MAPK10 (0.45) | NPC1RAB9ATNIKMAPK10MAPK8 | |
| SCHEMBL1666461 | 0.86 | MAPT (0.50) | NPC1RAB9AGFERTNIKMAPK10 | |
| SCHEMBL1664777 | 0.85 | MAPK10 (0.41) | NPC1RAB9ATNIKMAPK10MAPK8 | |
| SCHEMBL1664967 | 0.85 | NPC1 (0.71) | NPC1RAB9AGFERTNIKNAMPT | |
| SCHEMBL1663342 | 0.85 | MAOB (0.52) | NPC1RAB9ATNIKMAPK10MAPK8 | |
| SCHEMBL1664474 | 0.84 | TNIK (0.46) | NPC1RAB9ATNIKMAPK10MAPK8 | |
| SCHEMBL6126509 | 0.84 | SMN1; SMN2 (0.45) | NPC1RAB9AGFERTNIKMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |