Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.43 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665600 | 0.93 | EGFR (0.47) | NPC1RAB9ALMNASMN1; SMN2TNIK | |
| SCHEMBL1665212 | 0.86 | NPC1 (0.53) | NPC1RAB9ATNIKKDM1ARCOR1 | |
| SCHEMBL1663342 | 0.84 | MAOB (0.52) | NPC1RAB9ASMN1; SMN2TNIKMAPK10 | |
| SCHEMBL1665067 | 0.83 | MAPK10 (0.42) | NPC1RAB9ALMNASMN1; SMN2TNIK | |
| SCHEMBL1666461 | 0.83 | MAPT (0.50) | NPC1RAB9ASMN1; SMN2TNIKMAPK10 | |
| SCHEMBL1665219 | 0.82 | MAPK10 (0.43) | NPC1RAB9ASMN1; SMN2TNIKEGFR | |
| SCHEMBL1663344 | 0.82 | MAOB (0.56) | NPC1RAB9ASMN1; SMN2TNIKMAPK10 | |
| SCHEMBL1664474 | 0.81 | TNIK (0.46) | NPC1RAB9ALMNASMN1; SMN2TNIK | |
| SCHEMBL1664303 | 0.81 | MAPK10 (0.45) | NPC1RAB9ASMN1; SMN2TNIKMAPK10 | |
| SCHEMBL6126509 | 0.81 | SMN1; SMN2 (0.45) | NPC1RAB9ASMN1; SMN2TNIKMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |