Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 11/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665351 | 0.97 | MAOB (0.42) | TNIKMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL1666178 | 0.96 | MAPK10 (0.41) | TNIKMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL1666179 | 0.94 | MAOB (0.41) | TNIKMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL1664634 | 0.88 | MAPK10 (0.51) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL1666777 | 0.87 | MAOB (0.44) | TNIKMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL1664637 | 0.87 | RAB9A (0.45) | TNIKMAPTKDM4ESMN1; SMN2USP2 | |
| SCHEMBL1663527 | 0.86 | MAPK10 (0.40) | TNIKMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL1664636 | 0.86 | RAB9A (0.45) | TNIKMAOBMAPTHPGDSMN1; SMN2 | |
| SCHEMBL1665065 | 0.85 | MAOB (0.47) | TNIKMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL1663342 | 0.85 | MAOB (0.52) | TNIKMAPK10MAPK8MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |