Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29049022 | 0.83 | MEN1 (0.43) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL25126862 | 0.83 | MEN1 (0.43) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL23562282 | 0.83 | MEN1 (0.43) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL3315842 | 0.80 | MEN1 (0.41) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL20811244 | 0.79 | MEN1 (0.40) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL20799596 | 0.79 | MEN1 (0.40) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL20799595 | 0.79 | MEN1 (0.40) | MEN1MAPK1KMT2AGAAEPHX2 | |
| Hydrochloric Acid SCHEMBL20296787 | 0.78 | MEN1 (0.41) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL31118700 | 0.78 | KMT2A (0.42) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL31118811 | 0.78 | KMT2A (0.42) | MEN1MAPK1KMT2AGAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057954-A2 | HETEROMAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Syros Pharmaceuticals, Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058163-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2015-04-23 | — | — | WO | disclosed |