Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20799596 | 1.00 | MEN1 (0.40) | MEN1MAPK1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL20811244 | 1.00 | MEN1 (0.40) | MEN1MAPK1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL17191703 | 0.81 | MEN1 (0.43) | MEN1MAPK1KMT2AHCRTR2GAA | |
| SCHEMBL17191704 | 0.81 | MAPK1 (0.40) | MEN1MAPK1KMT2AHCRTR2GAA | |
| SCHEMBL15908108 | 0.80 | MEN1 (0.44) | MEN1MAPK1KMT2AHCRTR2GAA | |
| SCHEMBL15306517 | 0.80 | MEN1 (0.44) | MEN1MAPK1KMT2AHCRTR2GAA | |
| SCHEMBL15306518 | 0.80 | MEN1 (0.44) | MEN1MAPK1KMT2AHCRTR2GAA | |
| SCHEMBL20810976 | 0.79 | MEN1 (0.39) | MEN1MAPK1KMT2AHCRTR2CACNA1H | |
| SCHEMBL16654033 | 0.79 | MEN1 (0.37) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL20811240 | 0.79 | MEN1 (0.37) | MEN1MAPK1KMT2ACHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020248972-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF | JS INNOPHARM (SHANGHAI) LTD (CN) | 2020-12-17 | — | — | WO | disclosed |
| US-10435389-B2 | Octahydrocyclopenta[c]pyrrole allosteric inhibitors of SHP2 | Krouzon Pharmaccuticals, Inc. (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190077792-A1 | Octahydrocyclopenta[c]pyrrole Allosteric Inhibitors of SHP2 | Krouzon Pharmaceuticals, Inc. | 2019-03-14 | — | — | US | disclosed |
| WO-2019051469-A1 | OCTAHYDROCYCLOPENTA[C]PYRROLE ALLOSTERIC INHIBITORS OF SHP2 | Krouzon Pharmaceuticals, Inc. (US) | 2019-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077792-A1 | Octahydrocyclopenta[c]pyrrole Allosteric Inhibitors of SHP2 | PTPN1, PTPN2, PTPN7 | MEN1 3918/4885MAPK1 338/4885KMT2A 1077/4885 |
| US-10435389-B2 | Octahydrocyclopenta[c]pyrrole allosteric inhibitors of SHP2 | PTPN1, PTPN2, PTPN7 | MEN1 3918/4885MAPK1 338/4885KMT2A 1077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.