Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 16/20 | 0.64 |
| ▸ | CDK9 | P50750 | 16/20 | 0.64 |
| ▸ | CDK7 | P50613 | 16/20 | 0.64 |
| ▸ | CCNH | P51946 | 16/20 | 0.64 |
| ▸ | MNAT1 | P51948 | 11/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.61 |
| ▸ | CDK2 | P24941 | 9/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.60 |
| ▸ | CCNK | O75909 | 12/20 | 0.59 |
| ▸ | CDK12 | Q9NYV4 | 12/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.59 |
| ▸ | CDK13 | Q14004 | 8/20 | 0.57 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.57 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16653869 | 0.90 | CCNT1 (0.64) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL16654856 | 0.89 | CCNT1 (0.65) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL16665759 | 0.89 | CCNT1 (0.65) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL16655186 | 0.88 | CCNT1 (0.69) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL21397482 | 0.88 | CCNT1 (0.69) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL16655099 | 0.88 | CCNT1 (0.69) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL21397428 | 0.88 | CCNT1 (0.69) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL16654816 | 0.85 | CDK7 (0.74) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL21397381 | 0.83 | EGFR (0.70) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL21397471 | 0.81 | CDK9 (0.64) | CCNT1CDK9CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057954-A2 | HETEROMAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Syros Pharmaceuticals, Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058163-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2015-04-23 | — | — | WO | disclosed |