Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 19/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | YES1 | P07947 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.57 |
| ▸ | AXL | P30530 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | NEK4 | P51957 | 1/20 | 0.57 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.57 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.57 |
| ▸ | MERTK | Q12866 | 1/20 | 0.57 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.57 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654719 | 0.84 | RIPK1 (0.71) | RIPK1NTRK1CYP1A2LCKYES1 | |
| SCHEMBL16654450 | 0.81 | RIPK1 (0.67) | RIPK1NTRK1CYP1A2LCKYES1 | |
| SCHEMBL16660364 | 0.80 | RIPK1 (0.66) | RIPK1NTRK1CYP1A2LCKYES1 | |
| SCHEMBL868831 | 0.78 | RIPK1 (0.65) | RIPK1NTRK1CYP1A2LCKYES1 | |
| SCHEMBL16386454 | 0.78 | RIPK1 (0.59) | RIPK1NTRK1CYP1A2LCKYES1 | |
| SCHEMBL2427223 | 0.77 | RIPK1 (0.59) | RIPK1NTRK1CYP1A2LCKYES1 | |
| SCHEMBL868466 | 0.76 | RIPK1 (1.00) | RIPK1NTRK1CYP1A2LCKYES1 | |
| SCHEMBL14655478 | 0.76 | RIPK1 (0.56) | RIPK1NTRK1CYP1A2LCKYES1 | |
| SCHEMBL869066 | 0.76 | RIPK1 (0.55) | RIPK1NTRK1CYP1A2LCKYES1 | |
| SCHEMBL6925368 | 0.76 | RIPK1 (0.73) | RIPK1NTRK1CYP1A2LCKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015056180-A1 | INDOLINE DERIVATIVES AS INHIBITORS OF PERK | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015056180-A1 | INDOLINE DERIVATIVES AS INHIBITORS OF PERK | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |