Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 5/20 | 0.42 |
| ▸ | HTR6 | P50406 | 12/20 | 0.41 |
| ▸ | CCNH | P51946 | 4/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19024463 | 0.91 | HTR6 (0.43) | CDK7HTR6CCNHMNAT1CCNT1 | |
| SCHEMBL19024554 | 0.91 | CDK7 (0.49) | CDK7HTR6CCNHMNAT1CCNT1 | |
| SCHEMBL19024511 | 0.90 | HTR6 (0.40) | CDK7HTR6CCNHMNAT1CCNT1 | |
| SCHEMBL18047285 | 0.86 | CDK7 (0.51) | CDK7HTR6CCNHMNAT1CCNT1 | |
| SCHEMBL18047287 | 0.86 | CDK7 (0.51) | CDK7HTR6CCNHMNAT1CCNT1 | |
| SCHEMBL16654931 | 0.85 | CDK7 (0.45) | CDK7HTR6CCNHMNAT1CCNT1 | |
| SCHEMBL16654926 | 0.85 | CDK7 (0.45) | CDK7HTR6CCNHMNAT1CCNT1 | |
| SCHEMBL17688360 | 0.84 | CDK7 (0.46) | CDK7HTR6CCNHMNAT1CCNT1 | |
| SCHEMBL17688376 | 0.84 | CDK7 (0.45) | CDK7HTR6CCNHMNAT1CCNT1 | |
| SCHEMBL28348915 | 0.84 | CDK7 (0.46) | CDK7HTR6CCNHMNAT1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057956-A1 | POLYCYCLIC INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Dana-Farber Cancer Institute, Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058140-A1 | POLYCYCLIC INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-04-23 | — | — | WO | disclosed |