Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 7/20 | 0.37 |
| ▸ | CDK9 | P50750 | 6/20 | 0.37 |
| ▸ | CCNH | P51946 | 6/20 | 0.37 |
| ▸ | CCNK | O75909 | 5/20 | 0.37 |
| ▸ | CDK13 | Q14004 | 5/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.37 |
| ▸ | CDK2 | P24941 | 5/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.37 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21234246 | 0.96 | LCK (0.42) | HTR6BCHELCKCDK7CDK9 | |
| SCHEMBL18068876 | 0.91 | CCNK (0.42) | HTR6BCHELCKPADI4CDK7 | |
| SCHEMBL30886776 | 0.87 | HTR6 (0.43) | HTR6BCHECDK7CDK9CCNH | |
| SCHEMBL16655056 | 0.85 | CDK7 (0.48) | CDK7CDK9CCNHCCNKCDK13 | |
| SCHEMBL18045081 | 0.85 | CDK7 (0.48) | CDK7CDK9CCNHCCNKCDK13 | |
| SCHEMBL16655165 | 0.85 | HTR6 (0.46) | HTR6BCHELCKCDK7CDK9 | |
| SCHEMBL16655163 | 0.83 | HTR6 (0.57) | HTR6BCHELCKCDK9CCNT1 | |
| SCHEMBL16655415 | 0.83 | CDK2 (0.48) | CDK7CDK9CCNHCCNKCDK13 | |
| SCHEMBL16654808 | 0.83 | CDK2 (0.48) | CDK7CDK9CCNHCCNKCDK13 | |
| SCHEMBL16654810 | 0.83 | CDK2 (0.48) | CDK7CDK9CCNHCCNKCDK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11040957-B2 | Heteroaromatic compounds useful for the treatment of proliferative diseases | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-06-22 | — | — | US | disclosed |
| US-20190241541-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2019-08-08 | — | — | US | disclosed |
| EP-3057955-B1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | SYROS PHARMACEUTICALS INC (US) | 2018-04-11 | — | — | EP | disclosed |
| US-20160264551-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | SYROS PHARMACEUTICALS, INC. (US) | 2016-09-15 | — | — | US | disclosed |
| EP-3057955-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Syros Pharmaceuticals, Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058126-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | SYROS PHARMACEUTICALS, INC. (US) | 2015-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190241541-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | CDK7, CDK3, CDK4 | HTR6 3026/4885BCHE 4706/4885LCK 331/4885 |
| US-11040957-B2 | Heteroaromatic compounds useful for the treatment of proliferative diseases | CDK7, CDK3, CDK4 | HTR6 3026/4885BCHE 4706/4885LCK 331/4885 |
| US-20160264551-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | CDK7, CDK6, CDK3 | HTR6 2956/4885BCHE 4772/4885LCK 605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.