Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822622 | 0.86 | GAA (0.48) | SMN1; SMN2USP2CYP3A4MAPK1HTT | |
| SCHEMBL4404488 | 0.81 | KDM4E (0.47) | SMN1; SMN2USP2CYP3A4MAPK1HTT | |
| SCHEMBL4409280 | 0.78 | SMN1; SMN2 (0.41) | KMT2ASMN1; SMN2USP2CYP3A4MAPK1 | |
| SCHEMBL9223895 | 0.70 | KDM4E (0.47) | SMN1; SMN2CYP3A4HTTNPC1RAB9A | |
| SCHEMBL15725747 | 0.69 | KDM4E (0.47) | SMN1; SMN2USP2HTTMAPTNPSR1 | |
| SCHEMBL3970999 | 0.69 | GAA (0.50) | SMN1; SMN2USP2CYP3A4MAPK1HTT | |
| SCHEMBL16069727 | 0.69 | SOS1 (0.48) | KMT2ACYP3A4HTTNPC1RAB9A | |
| SCHEMBL205044 | 0.68 | KDM4E (0.50) | SMN1; SMN2USP2CYP3A4MAPK1HTT | |
| SCHEMBL20397117 | 0.68 | KDM4E (0.46) | SMN1; SMN2USP2MAPTPOLBKDM4E | |
| SCHEMBL1559038 | 0.68 | KDM4E (0.50) | CYP3A4HTTMAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |