Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.74 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.62 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535265 | 0.85 | HDAC6 (1.00) | HDAC6HDAC5HDAC4HDAC1HDAC8 | |
| SCHEMBL20535891 | 0.81 | HDAC6 (0.73) | HDAC6HDAC5HDAC4HDAC1HDAC8 | |
| SCHEMBL19682901 | 0.80 | HDAC6 (0.72) | HDAC6HDAC5HDAC4HDAC1HDAC8 | |
| SCHEMBL16655216 | 0.77 | HDAC6 (0.73) | HDAC6HDAC5HDAC1HDAC8HDAC3 | |
| SCHEMBL16653782 | 0.77 | HDAC6 (1.00) | HDAC6HDAC5HDAC4HDAC1HDAC8 | |
| SCHEMBL19666006 | 0.77 | HDAC6 (1.00) | HDAC6HDAC5HDAC4HDAC1HDAC8 | |
| SCHEMBL19666090 | 0.77 | HDAC6 (1.00) | HDAC6HDAC5HDAC4HDAC1HDAC8 | |
| SCHEMBL16653780 | 0.77 | HDAC6 (1.00) | HDAC6HDAC5HDAC4HDAC1HDAC8 | |
| SCHEMBL19678427 | 0.77 | HDAC6 (1.00) | HDAC6HDAC5HDAC4HDAC1HDAC8 | |
| SCHEMBL18085897 | 0.74 | HDAC6 (0.94) | HDAC6HDAC5HDAC4HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3062783-A1 | IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY | The General Hospital Corporation DBA Massachusetts (US) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015058106-A1 | IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY | THE GENERAL HOSPITAL CORPORATION (US) | 2015-04-23 | — | — | WO | disclosed |