Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535185 | 0.84 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC2P2RX7 | |
| SCHEMBL18423583 | 0.78 | HDAC6 (0.70) | HDAC6HDAC3HDAC1HDAC2P2RX7 | |
| SCHEMBL18460736 | 0.78 | HDAC6 (0.62) | HDAC6HDAC3HDAC1HDAC2P2RX7 | |
| SCHEMBL16655138 | 0.77 | HDAC6 (0.74) | HDAC6HDAC3HDAC1HDAC2P2RX7 | |
| SCHEMBL2404317 | 0.75 | HDAC1 (1.00) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2404324 | 0.75 | HDAC1 (1.00) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL18088397 | 0.72 | HDAC6 (0.61) | HDAC6HDAC3HDAC1HDAC2P2RX7 | |
| SCHEMBL10067533 | 0.72 | P2RX7 (0.67) | HDAC6HDAC3HDAC1HDAC2P2RX7 | |
| SCHEMBL16653762 | 0.71 | HDAC6 (0.74) | HDAC6HDAC3HDAC1HDAC2P2RX7 | |
| SCHEMBL20535184 | 0.71 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3062783-A1 | IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY | The General Hospital Corporation DBA Massachusetts (US) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015058106-A1 | IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY | THE GENERAL HOSPITAL CORPORATION (US) | 2015-04-23 | — | — | WO | disclosed |