Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 13/20 | 0.48 |
| ▸ | CCNH | P51946 | 12/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.40 |
| ▸ | CCNK | O75909 | 4/20 | 0.40 |
| ▸ | CDK9 | P50750 | 4/20 | 0.40 |
| ▸ | CDK13 | Q14004 | 4/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18047405 | 0.93 | CDK7 (0.58) | CDK7CCNHCDK12CCNT1CCNK | |
| SCHEMBL18047404 | 0.93 | CDK7 (0.58) | CDK7CCNHCDK12CCNT1CCNK | |
| SCHEMBL16655060 | 0.87 | CDK7 (0.41) | CDK7CCNHEGFRHTR6TRIM24 | |
| SCHEMBL17141331 | 0.80 | CDK7 (0.61) | CDK7CCNHEGFRCDK12CCNT1 | |
| SCHEMBL18047421 | 0.78 | HTR6 (0.47) | EGFRHTR6 | |
| SCHEMBL15648828 | 0.76 | CDK5 (0.59) | CDK7CCNHCDK12CCNT1CCNK | |
| SCHEMBL29174624 | 0.74 | CDK7 (0.58) | CDK7CCNHEGFRCDK12CCNT1 | |
| SCHEMBL16655057 | 0.74 | CCNK (0.65) | CDK7CCNHCDK12CCNT1CCNK | |
| SCHEMBL16655058 | 0.74 | CCNK (0.65) | CDK7CCNHCDK12CCNT1CCNK | |
| SCHEMBL18078643 | 0.74 | CDK7 (0.76) | CDK7CCNHEGFRCDK12CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057954-A2 | HETEROMAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Syros Pharmaceuticals, Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058163-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2015-04-23 | — | — | WO | disclosed |