Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.57 |
| ▸ | FNTA | P49354 | 1/20 | 0.56 |
| ▸ | FNTB | P49356 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL18042462 | 1.00 | KMT2A (0.64) | KMT2AGGPS1MAPTALDH1A1MEN1 | |
| Phosphoric Acid SCHEMBL2970524 | 1.00 | KMT2A (0.64) | KMT2AGGPS1MAPTALDH1A1MEN1 | |
| Squalene SCHEMBL27769242 | 0.91 | KMT2A (0.77) | KMT2AGGPS1MAPTALDH1A1MEN1 | |
| Squalene SCHEMBL27745351 | 0.91 | KMT2A (0.77) | KMT2AGGPS1MAPTALDH1A1MEN1 | |
| Squalene SCHEMBL28409601 | 0.91 | KMT2A (0.77) | KMT2AGGPS1MAPTALDH1A1MEN1 | |
| Squalene SCHEMBL27745343 | 0.91 | KMT2A (0.77) | KMT2AGGPS1MAPTALDH1A1MEN1 | |
| SCHEMBL6716175 | 0.89 | KMT2A (0.80) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL3092587 | 0.89 | KMT2A (0.80) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL12713311 | 0.89 | KMT2A (0.80) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL3090339 | 0.89 | KMT2A (0.80) | KMT2AMAPTALDH1A1MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057975-A1 | N-GLYCOSYLATION OF PEPTIDES AND PROTEINS | Oxford University Innovation Limited (GB) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015056011-A1 | N-GLYCOSYLATION OF PEPTIDES AND PROTEINS | ISIS INNOVATION LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |