Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | CCR8 | P51685 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488519 | 0.78 | TRPV1 (0.33) | MAPK9MAPK10IDO1TDO2 | |
| SCHEMBL4295168 | 0.74 | ROCK1 (0.40) | ROCK1 | |
| SCHEMBL28404695 | 0.72 | MAPK9 (0.37) | POLBMAPK9MAPK10 | |
| SCHEMBL3452399 | 0.70 | MAPT (0.39) | MAPK9MAPK10IDO1TDO2 | |
| SCHEMBL27523149 | 0.70 | MAPK9 (0.38) | POLBMAPK9MAPK10 | |
| SCHEMBL28488709 | 0.68 | MAPK9 (0.35) | MAPK9MAPK10 | |
| SCHEMBL4256516 | 0.68 | MAPK9 (0.35) | POLBMAPK9MAPK10ROCK1 | |
| SCHEMBL2014685 | 0.67 | TGFBR1 (0.39) | MAPK9MAPK10 | |
| SCHEMBL558541 | 0.67 | MAPK9 (0.39) | POLBMAPK9MAPK10 | |
| SCHEMBL30463164 | 0.67 | MAPK9 (0.34) | POLBMAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |