Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 19/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.50 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16633446 | 0.88 | RORC (0.65) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16639445 | 0.82 | RORC (0.64) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16654311 | 0.79 | RORC (0.74) | RORC | |
| SCHEMBL16654443 | 0.78 | RORC (0.78) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16632681 | 0.78 | RORC (0.78) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16639471 | 0.73 | RORC (0.77) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16632953 | 0.72 | RORC (0.83) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16633023 | 0.71 | RORC (0.75) | RORC | |
| SCHEMBL16653900 | 0.71 | RORC (0.44) | RORC | |
| SCHEMBL16633126 | 0.71 | RORC (0.84) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | Janssen Pharmaceutica N.V. (BE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057205-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-23 | — | — | WO | disclosed |