Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 9/20 | 0.61 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 8/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13861216 | 0.77 | EIF2AK3 (0.61) | EIF2AK3RIPK1MAPTRAB9A | |
| SCHEMBL16156132 | 0.76 | EIF2AK3 (0.58) | EIF2AK3 | |
| SCHEMBL869007 | 0.76 | EIF2AK3 (1.00) | EIF2AK3RIPK1 | |
| SCHEMBL868181 | 0.75 | EIF2AK3 (0.66) | EIF2AK3EIF2AK2RIPK1LCKKDR | |
| SCHEMBL869564 | 0.74 | EIF2AK3 (0.81) | EIF2AK3EIF2AK2RIPK1 | |
| SCHEMBL869455 | 0.72 | EIF2AK3 (0.55) | EIF2AK3NPC1MAPTRAB9A | |
| SCHEMBL16386452 | 0.72 | EIF2AK3 (0.80) | EIF2AK3RIPK1 | |
| SCHEMBL16654949 | 0.71 | EIF2AK3 (0.58) | EIF2AK3EIF2AK2RIPK1NPC1GAA | |
| SCHEMBL868634 | 0.71 | EIF2AK3 (1.00) | EIF2AK3EIF2AK2RIPK1LCK | |
| SCHEMBL2385135 | 0.70 | EIF2AK3 (0.72) | EIF2AK3EIF2AK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015056180-A1 | INDOLINE DERIVATIVES AS INHIBITORS OF PERK | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015056180-A1 | INDOLINE DERIVATIVES AS INHIBITORS OF PERK | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |