Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 19/20 | 0.72 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27975806 | 0.87 | EIF2AK3 (0.74) | EIF2AK3EIF2AK1LCKAURKB | |
| SCHEMBL868836 | 0.84 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1LCKAURKB | |
| SCHEMBL869043 | 0.80 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1LCKAURKBEIF2AK2 | |
| SCHEMBL868818 | 0.80 | EIF2AK3 (0.74) | EIF2AK3EIF2AK1LCKAURKBEIF2AK2 | |
| SCHEMBL869377 | 0.77 | EIF2AK3 (0.76) | EIF2AK3EIF2AK1LCKAURKBEIF2AK2 | |
| SCHEMBL868470 | 0.77 | EIF2AK3 (0.75) | EIF2AK3EIF2AK1LCKAURKBEIF2AK2 | |
| SCHEMBL868891 | 0.76 | EIF2AK3 (0.67) | EIF2AK3EIF2AK1LCKAURKBEIF2AK2 | |
| SCHEMBL16156132 | 0.75 | EIF2AK3 (0.58) | EIF2AK3MAPK1 | |
| SCHEMBL30361395 | 0.74 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1EIF2AK2 | |
| SCHEMBL869204 | 0.74 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |