Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC5 | O15392 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2846087 | 0.85 | BIRC5 (0.55) | BIRC5PDGFRBPDGFRACYP2A6CA12 | |
| SCHEMBL28286294 | 0.79 | PDGFRB (0.54) | BIRC5PDGFRBPDGFRACYP2A6CA12 | |
| SCHEMBL27191399 | 0.77 | PDGFRB (0.61) | BIRC5PDGFRBPDGFRACYP2A6CA12 | |
| SCHEMBL30911075 | 0.76 | BIRC5 (0.55) | BIRC5PDGFRBPDGFRACYP2A6CA12 | |
| SCHEMBL15949762 | 0.76 | BIRC5 (0.55) | BIRC5PDGFRBPDGFRACYP2A6CA12 | |
| SCHEMBL28284755 | 0.75 | PDGFRB (0.50) | BIRC5PDGFRBPDGFRACYP2A6PIK3CD | |
| SCHEMBL32667946 | 0.74 | PDGFRB (0.77) | BIRC5PDGFRBPDGFRACYP2A6CA12 | |
| SCHEMBL2772360 | 0.74 | PDGFRB (0.77) | BIRC5PDGFRBPDGFRACYP2A6CA12 | |
| SCHEMBL29060493 | 0.74 | PDGFRB (0.66) | BIRC5PDGFRBPDGFRACYP2A6CA12 | |
| SCHEMBL29375315 | 0.74 | PDGFRB (0.66) | BIRC5PDGFRBPDGFRACYP2A6CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057950-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | Janssen Pharmaceutica N.V. (BE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057203-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-23 | — | — | WO | disclosed |