Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | HINT1 | P49773 | 4/20 | 0.57 |
| ▸ | NT5E | P21589 | 2/20 | 0.57 |
| ▸ | PNP | P00491 | 2/20 | 0.56 |
| ▸ | CD99 | P14209 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| F-Arag SCHEMBL313467 | 1.00 | PDE2A (0.64) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| F-Arag SCHEMBL9489885 | 1.00 | PDE2A (0.64) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| F-Arag SCHEMBL12150772 | 1.00 | PDE2A (0.64) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| F-Arag SCHEMBL14163604 | 1.00 | PDE2A (0.64) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| F-Arag SCHEMBL12300492 | 1.00 | PDE2A (0.64) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| F-Arag SCHEMBL236684 | 1.00 | PDE2A (0.64) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| F-Arag SCHEMBL35286 | 1.00 | PDE2A (0.64) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| F-Arag SCHEMBL20581034 | 1.00 | PDE2A (0.64) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| F-Arag SCHEMBL21625251 | 1.00 | PDE2A (0.64) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| F-Arag F-18 SCHEMBL29373858 | 1.00 | PDE2A (0.64) | PDE2AADORA3ADORA2AADORA1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230309833-A1 | METHODS AND MATERIALS FOR USING [18F]-F-ARAG IN CARDIAC IMAGING | CELLSIGHT TECHNOLOGIES INC. (US) | 2023-10-05 | — | — | US | disclosed |
| US-20150118157-A1 | Compounds and Methods of Making Compounds | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2015-04-30 | — | — | US | disclosed |
| US-9011817-B2 | Compounds and methods of making compounds | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2015-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150118157-A1 | Compounds and Methods of Making Compounds | MCL1, TOP2B, TOP1 | PDE2A 666/4885ADORA3 1555/4885ADORA2A 743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.