Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 13/20 | 0.73 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.70 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.65 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16659600 | 0.90 | FGFR2 (0.75) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16665288 | 0.84 | FGFR1 (1.00) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL17740756 | 0.83 | FGFR4 (1.00) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16659436 | 0.80 | FGFR1 (0.89) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16665256 | 0.80 | FGFR1 (0.77) | FGFR1FGFR4FGFR3FGFR2CYP3A4 | |
| SCHEMBL16665322 | 0.80 | FGFR1 (0.78) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16665378 | 0.80 | FGFR1 (0.78) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16654398 | 0.80 | FGFR1 (1.00) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16659606 | 0.79 | FGFR2 (1.00) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16659421 | 0.79 | FGFR4 (0.88) | FGFR1FGFR4FGFR3FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |