Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10797345 | 0.79 | ALDH1A1 (0.53) | MEN1KMT2ANPSR1HTR2CALDH1A1 | |
| SCHEMBL12656081 | 0.78 | MEN1 (0.49) | MEN1KMT2ANPSR1HTR2CNPC1 | |
| SCHEMBL3792418 | 0.77 | MEN1 (0.50) | MEN1KMT2ANPSR1HTR2CALDH1A1 | |
| SCHEMBL14617627 | 0.76 | HTR2C (0.48) | MEN1KMT2ANPSR1HTR2CALDH1A1 | |
| SCHEMBL2072822 | 0.76 | MEN1 (0.53) | MEN1KMT2ANPSR1HTR2CNPC1 | |
| SCHEMBL7245273 | 0.76 | MEN1 (0.49) | MEN1KMT2ANPSR1HTR2CALDH1A1 | |
| SCHEMBL630773 | 0.76 | MEN1 (0.49) | MEN1KMT2ANPSR1HTR2CALDH1A1 | |
| SCHEMBL15541400 | 0.76 | ALDH1A1 (0.46) | MEN1KMT2ANPSR1HTR2CALDH1A1 | |
| SCHEMBL1834783 | 0.75 | HTR2C (0.49) | MEN1KMT2ANPSR1HTR2CALDH1A1 | |
| SCHEMBL542153 | 0.75 | HTR2C (0.49) | MEN1KMT2ANPSR1HTR2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486042-A1 | BICYCLIC HETEROCYCLES AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011042399-A1 | BICYCLIC HETEROCYCLES AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-04-14 | — | — | WO | disclosed |