Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 3/20 | 0.33 |
| ▸ | SRC | P12931 | 3/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | CSK | P41240 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL596609 | 0.86 | MAPT (0.43) | ADORA3MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL596608 | 0.86 | MAPT (0.43) | ADORA3MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL598052 | 0.77 | IGF1R (0.48) | ADORA3MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL598053 | 0.77 | IGF1R (0.48) | ADORA3MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL596643 | 0.76 | HTT (0.43) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL596644 | 0.76 | HTT (0.43) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL596637 | 0.75 | LMNA (0.44) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL597006 | 0.75 | AURKA (0.38) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL597007 | 0.75 | AURKA (0.38) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL596636 | 0.75 | LMNA (0.44) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928456-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS INC (US) | 2015-04-22 | — | — | EP | disclosed |