Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10122871 | 0.77 | AURKA (0.64) | AURKANTRK1LCKKDRFLT3 | |
| SCHEMBL597862 | 0.77 | AURKA (0.46) | AURKANTRK1LCKKDRFLT3 | |
| SCHEMBL14546532 | 0.72 | AURKA (0.52) | AURKANTRK1LCKKDRFLT3 | |
| SCHEMBL14546315 | 0.70 | AURKA (0.50) | AURKANTRK1LCKKDRFLT3 | |
| SCHEMBL14546305 | 0.69 | AURKA (0.49) | AURKANTRK1LCKKDRFLT3 | |
| SCHEMBL14546530 | 0.69 | AURKA (0.50) | AURKANTRK1LCKKDRFLT3 | |
| SCHEMBL16660274 | 0.67 | AURKA (0.46) | AURKANTRK1LCKKDRFLT3 | |
| SCHEMBL21744943 | 0.66 | DPP4 (0.40) | AURKARETCHEK1HRH4KMT2A | |
| SCHEMBL10312059 | 0.63 | AURKA (0.50) | AURKANTRK1LCKKDRFLT3 | |
| SCHEMBL14532247 | 0.62 | AURKA (0.47) | AURKANTRK1LCKKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928456-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS INC (US) | 2015-04-22 | — | — | EP | disclosed |