Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.77 |
| ▸ | KDR | P35968 | 5/20 | 0.77 |
| ▸ | GAK | O14976 | 3/20 | 0.75 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.75 |
| ▸ | STK10 | O94804 | 2/20 | 0.75 |
| ▸ | RET | P07949 | 2/20 | 0.75 |
| ▸ | FLT3 | P36888 | 2/20 | 0.75 |
| ▸ | JAK3 | P52333 | 2/20 | 0.75 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.75 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.75 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.75 |
| ▸ | KDM1A | O60341 | 2/20 | 0.75 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.75 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.75 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.75 |
| ▸ | LCK | P06239 | 2/20 | 0.73 |
| ▸ | FLT1 | P17948 | 2/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18447218 | 0.89 | KDM1A (0.77) | EGFRKDRGAKRIPK2STK10 | |
| SCHEMBL7708517 | 0.88 | EGFR (0.77) | EGFRKDRGAKKDM1ALCK | |
| SCHEMBL28105746 | 0.88 | KDR (0.75) | EGFRKDRGAKKDM1AFLT1 | |
| SCHEMBL20805304 | 0.88 | EGFR (0.77) | EGFRKDRGAKRIPK2STK10 | |
| SCHEMBL4477758 | 0.86 | EGFR (0.77) | EGFRKDRGAKRIPK2STK10 | |
| Whi-P131 SCHEMBL29295 | 0.86 | EGFR (1.00) | EGFRKDRGAKRIPK2STK10 | |
| Whi-P131 SCHEMBL29369589 | 0.86 | EGFR (1.00) | EGFRKDRGAKRIPK2STK10 | |
| SCHEMBL22381430 | 0.86 | KDM1A (0.72) | EGFRKDRGAKRIPK2STK10 | |
| SCHEMBL13219733 | 0.85 | EGFR (0.78) | EGFRKDRGAKRIPK2STK10 | |
| Whi-P131 SCHEMBL6068752 | 0.85 | EGFR (1.00) | EGFRKDRGAKRIPK2STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10759764-B2 | Fluorination of organic compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-09-01 | — | — | US | disclosed |
| US-20160272593-A1 | FLUORINATION OF ORGANIC COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-09-22 | — | — | US | disclosed |
| US-20160272593-A1 | FLUORINATION OF ORGANIC COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-09-22 | — | — | US | disclosed |
| WO-2015058047-A2 | FLUORINATION OF ORGANIC COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272593-A1 | FLUORINATION OF ORGANIC COMPOUNDS | FLI1, SLCO2B1, SLCO1B3 | EGFR 505/4885KDR 2531/4885GAK 1987/4885 |
| US-10759764-B2 | Fluorination of organic compounds | FLI1, SLCO2B1, SLCO1B3 | EGFR 505/4885KDR 2531/4885GAK 1987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.