Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.77 |
| ▸ | LCK | P06239 | 2/20 | 0.77 |
| ▸ | KDM1A | O60341 | 1/20 | 0.75 |
| ▸ | KDR | P35968 | 5/20 | 0.73 |
| ▸ | GAK | O14976 | 1/20 | 0.71 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.66 |
| ▸ | FLT1 | P17948 | 1/20 | 0.66 |
| ▸ | FBP1 | P09467 | 1/20 | 0.66 |
| ▸ | ILK | Q13418 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708102 | 0.92 | EGFR (0.67) | EGFRLCKKDM1AKDRGAK | |
| SCHEMBL18447218 | 0.89 | KDM1A (0.77) | EGFRLCKKDM1AKDRGAK | |
| SCHEMBL16660323 | 0.88 | EGFR (0.77) | EGFRLCKKDM1AKDRGAK | |
| SCHEMBL28105746 | 0.88 | KDR (0.75) | EGFRKDM1AKDRGAKFGFR1 | |
| SCHEMBL20805304 | 0.88 | EGFR (0.77) | EGFRLCKKDM1AKDRGAK | |
| SCHEMBL5472599 | 0.87 | EGFR (1.00) | EGFRLCKKDRGAKFLT1 | |
| Hydrochloric Acid SCHEMBL5479915 | 0.86 | EGFR (1.00) | EGFRLCKKDRGAKFLT1 | |
| SCHEMBL22381430 | 0.86 | KDM1A (0.72) | EGFRLCKKDM1AKDRGAK | |
| SCHEMBL13219733 | 0.85 | EGFR (0.78) | EGFRLCKKDM1AKDRGAK | |
| SCHEMBL30016831 | 0.81 | EGFR (0.60) | EGFRLCKKDM1AKDRGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105884653-A | Erlotinib derivative and preparing method thereof | 浙江汇能生物股份有限公司 | 2016-08-24 | — | — | CN | disclosed |
| US-6476040-B1 | Processes and intermediates for preparing anti-cancer compounds | PFIZER INC. | 2002-11-05 | — | — | US | disclosed |
| EP-1044969-A2 | Processes and intermediates for preparing anti-cancer compounds | Pfizer Products Inc. (US) | 2000-10-18 | — | — | EP | disclosed |