Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MST1R | Q04912 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105274 | 0.91 | MET (0.39) | MST1RMAPTPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL105275 | 0.91 | MET (0.39) | MST1RMAPTPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL171881 | 0.91 | MST1R (0.50) | MST1RMETKDRNTRK1KIT | |
| SCHEMBL2602366 | 0.84 | MST1R (0.44) | MST1RMETKDR | |
| SCHEMBL13927478 | 0.80 | MST1R (0.38) | MST1R | |
| SCHEMBL106463 | 0.79 | MST1R (0.52) | MST1RMETKDRNTRK1KIT | |
| SCHEMBL16660464 | 0.79 | MAPT (0.37) | MST1RMAPTPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL16660462 | 0.79 | MAPT (0.37) | MST1RMAPTPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL16660454 | 0.79 | HDAC3 (0.34) | MST1RPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL13166757 | 0.78 | MST1R (0.50) | MST1RMAPTPOLBSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9018378-B2 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | METHYLGENE INC. (CA) | 2015-04-28 | — | — | US | disclosed |