Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655580 | 0.90 | SYK (0.59) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL656343 | 0.90 | SYK (0.61) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL655064 | 0.90 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL3838798 | 0.90 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL655063 | 0.90 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL3838802 | 0.90 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL28757177 | 0.89 | SYK (0.49) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL656933 | 0.86 | SYK (0.66) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL3835126 | 0.86 | SYK (0.61) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL656932 | 0.86 | SYK (0.66) | SYKAURKAMAPK8AURKBCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9018204-B1 | 2,4-pyrimidinediamine compounds and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2015-04-28 | — | — | US | disclosed |