Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.65 |
| ▸ | AURKA | O14965 | 3/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | ITK | Q08881 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3838798 | 1.00 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL655063 | 1.00 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL655064 | 1.00 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL655581 | 0.90 | SYK (0.60) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL16660488 | 0.90 | SYK (0.62) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL655580 | 0.89 | SYK (0.59) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL657318 | 0.89 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL657319 | 0.89 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL656040 | 0.88 | SYK (0.68) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL656041 | 0.88 | SYK (0.68) | SYKAURKAMAPK8AURKBCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2130541-A2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | Rigel Pharmaceuticals, Inc. (US) | 2009-12-09 | — | — | EP | claimed |